Lewy Body Disease
Lewy Body Disease
(Lewy Body Dementia; Dementia with Lewy Bodies)
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- Parkinson's disease
- Multiple system atrophy
- Alzheimer's disease
- Other disorders
- Gender: male
- Age: 53-83 years
- Family history of Lewy body disease, Parkinson's disease, or other dementias
- Fluctuations in alertness and attention—frequent drowsiness, lethargy, staring into space, disorganized speech, and insomnia
- Recurrent visual hallucinations
- Poor regulation of body temperature and blood pressure
- Obsessive compulsive behaviors
- Parkinsonian motor symptoms—rigidity, loss of spontaneous movement
- REM behavior disorder
- Donepezil and rivastigmine—to help with cognition; may worsen motor symptoms
- Memantine—to improve behavioral symptoms
- Levodopa—to help control rigidity and loss of spontaneous movement
Lewy Body Dementia Association http://www.lewybodydementia.org
National Institute of Neurological Disorders and Stroke http://www.ninds.nih.gov
Alzheimer Society http://www.alzheimer.ca
Canadian Stroke Network http://www.canadianstrokenetwork.ca
Ballard CG, Chalmers KA, Todd C, et al. Cholinesterase inhibitors reduce cortical Abeta in dementia with Lewy bodies. Neurology . 2007;68:1726-1729.
Bouchard RW. Diagnostic criteria of dementia [review]. Can J Neurol Sci . 2007;34:(Suppl 1)S11-18.
Camicioli R, Gauthier S. Clinical trials in Parkinson's disease dementia and dementia with Lewy bodies [review]. Can J Neurol Sci . 2007;34:(Suppl 1)S109-117.
Chou KL, Borek LL, Friedman JH. The management of psychosis in movement disorder patients [review]. Expert Opin Pharmacother . 2007;8:935-943.
Dementia with Lewy bodies. EBSCO DynaMed website. Available at: http://www.ebscohost.com/dynamed/ . Updated September 11, 2012. Accessed February 21, 2013.
Dementia with Lewy bodies information page. National Institute of Neurological Disorders and Stroke website. Available at: http://www.ninds.nih.gov/disorders/dementiawithlewybodies/dementiawithlewybodies.htm . Updated May 16, 2012. Accessed February 21, 2013.
Emre M, Tsolaki M, Bonnucelli U, et al. Memantine for patients with Parkinson’s disease dementia or dementia with Lewey bodies: a randomised, double-blind, placebo controlled trial. Lancet Neurol . 2010;9(10):969-77.
Goldmann Gross R, Siderowf A, Hurtig HI. Cognitive impairment in Parkinson’s disease and dementia with Lewy bodies: a spectrum of disease. Neurosignals . 2008;16:24-34.
Jellinger KA. Formation and development of Lewy pathology: a critical update. J Neurol . 2009;256(Suppl 3):270-279.
Kemp PM, Hoffmann SA, Tossici-Bolt L, Fleming JS, Holmes C. Limitations of the HMPAO SPECT appearances of occipital lobe perfusion in the differential diagnosis of dementia with Lewy bodies. Nucl Med Commun . 2007;28:451-456.
Lewy body disease: LBD. Lewy Body Disease Association website. Available at: http://lbda.org/sites/default/files/booklet-for-newly-diagnosed-patients2.pdf . Accessed February 21, 2013.
Meeus B, et al. The genetics of dementia with Lewy bodies: what are we missing? Arch Neurol . 2012;69(9):1113-8.
Tarawneh R, Galvin JE. Distinguishing Lewy body dementias from Alzheimer’s disease. Expert Review of Neurotherapeautics . 2007;7:1499-1516.
Weintraub D, Hurtig HI. Presentation and management of psychosis in Parkinson’s disease and dementia with Lewy bodies. Am J. Psychiatry . 2007;164:1491-1498.
- Reviewer: Rimas Lukas, MD
- Review Date: 03/2013 -
- Update Date: 03/15/2013 -